MK 8591

Drug Profile

MK 8591

Alternative Names: 4-ethynyl-2-fluoro-2-deoxyadenosine; EFdA; MK-8591

Latest Information Update: 24 Apr 2018

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At a glance

  • Originator Merck Sharp & Dohme
  • Class Antiretrovirals
  • Mechanism of Action Nucleoside reverse transcriptase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II HIV-1 infections
  • Preclinical HIV-2 infections

Most Recent Events

  • 04 Mar 2018 Clinical trials in HIV-1 infections (In volunteers) in USA (PO) before March 2018
  • 04 Mar 2018 Pharmacokinetics and adverse events data from a clinical trial in HIV-1 infections presented at the 25th Conference on Retroviruses and Opportunistic Infections (CROI-2018)
  • 27 Nov 2017 Phase-II clinical trials in HIV-1 infections (Treatment-naive, Combination therapy) in USA (PO) (NCT03272347)
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