Inclisiran - Alnylam Pharmaceuticals

Drug Profile

Inclisiran - Alnylam Pharmaceuticals

Alternative Names: ALN-60212; ALN-PCSsc; PCSK9si

Latest Information Update: 04 Jul 2018

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At a glance

  • Originator Alnylam Pharmaceuticals
  • Developer Alnylam Pharmaceuticals; The Medicines Company
  • Class Amino sugars; Antihyperlipidaemics; Drug conjugates; Small interfering RNA
  • Mechanism of Action PCSK9 protein inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hypercholesterolaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Hypercholesterolaemia

Most Recent Events

  • 27 Jun 2018 An Independent Data Monitoring Committee (IDMC) recommends continuation of the phase III ORION trials in Hypercholesterolaemia without modification
  • 26 Jun 2018 Adverse events and efficacy data from the phase II ORION-1 trial in Hypercholesterolaemia presented at the American Diabetes Association 78th Scientific Sessions (ADA-2018)
  • 03 May 2018 The Medicines Company plans the ORION-4 cardiovascular outcomes trial in mid-2018
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