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H 1129

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Drug Profile

H 1129

Alternative Names: H-1129; WP-1303

Latest Information Update: 15 Apr 2026

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At a glance

  • Originator D. Western Therapeutics Institute
  • Developer D. Western Therapeutics Institute; Wakamoto
  • Class Anti-inflammatories; Antiglaucomas; Eye disorder therapies; Quinolines; Small molecules; Sulfonamides
  • Mechanism of Action HSP90 heat-shock protein inhibitors; Rho-associated kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Keratoconjunctivitis
  • Discontinued Ocular hypertension; Open-angle glaucoma

Most Recent Events

  • 15 Apr 2026 Preclinical trials in Keratoconjunctivitis in Japan (unspecified route) prior to April 2026 (D. Western Therapeutics Institute pipeline, April 2026)
  • 22 Dec 2021 Wakamoto terminates a phase III comparison study in Glaucoma and Ocular hypertension in Japan (JapicCTI194920)
  • 22 Dec 2021 Wakamoto terminates a phase III in Glaucoma and Ocular hypertension (Combination therapy) (Ophthalmic) in Japan (JapicCTI194921)

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