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Numidargistat - Calithera Biosciences

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Drug Profile

Numidargistat - Calithera Biosciences

Alternative Names: CB-1158; INCB 001158; INCB 01158

Latest Information Update: 28 Mar 2023

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At a glance

  • Originator Mars Symbioscience
  • Developer Calithera Biosciences; Incyte Corporation
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Arginase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Multiple myeloma; Solid tumours

Most Recent Events

  • 20 Mar 2023 Incyte Corporation terminates a phase I/II trial in Multiple myeloma (Second-line therapy or greater, Combination therapy) in USA, Spain and Germany (PO) due to recruitment difficulties (NCT03837509) (EudraCT2018-004076-35)
  • 09 Jan 2023 Discontinued - Phase-I for Solid tumours (Combination therapy, Late-stage disease, Metastatic disease) in Japan (PO)
  • 09 Jan 2023 Discontinued - Phase-I for Solid tumours (Late-stage disease, Metastatic disease, Monotherapy) in Japan (PO)

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