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Anti-CD19 chimeric antigen receptor T cell therapy - Takara Bio

Drug Profile

Anti-CD19 chimeric antigen receptor T cell therapy - Takara Bio

Alternative Names: CD19 CAR gene transduced T lymphocytes - Takara Bio; CD19 chimeric antigen receptor T cell therapy - Takara Bio; CD19-CAR gene therapy - Takara Bio; CD19-CAR T cell therapy - Takara Bio; TBI-1501

Latest Information Update: 17 Nov 2021

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At a glance

  • Originator Memorial Sloan-Kettering Cancer Center
  • Developer Jichi Medical School; Otsuka Pharmaceutical; Takara Bio
  • Class Antineoplastics; CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase I/II Non-Hodgkin's lymphoma; Precursor B-cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 09 Nov 2021 Otsuka Pharmaceutical terminates development and licensing agreement with Takara Bio for anti-CD19 chimeric antigen receptor T cell therapy in Japan
  • 10 Apr 2018 Otsuka Pharmaceutical and Takara Bio agree to co-promote [and co-develop] TBI 1301 in Japan for Cancer
  • 19 May 2017 Takara Bio plans a phase I/II trial for Acute lymphoblastic leukaemia (Second-line therapy or greater) in Japan (NCT03155191)
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