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Ritlecitinib - Pfizer

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Drug Profile

Ritlecitinib - Pfizer

Alternative Names: LITFULO; Litfulo; PF 06651600; PF 6651600; Ritlecitinib tosilate - Pfizer; Ritlecitinib tosylate - Pfizer

Latest Information Update: 22 Dec 2025

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At a glance

  • Originator Pfizer
  • Developer National Institute of Diabetes and Digestive and Kidney Diseases; Pfizer
  • Class Amines; Anti-inflammatories; Antihyperglycaemics; Antirheumatics; Antiulcers; Heterocyclic bicyclo compounds; Ketones; Piperidines; Pyrimidines; Pyrroles; Skin disorder therapies; Small molecules
  • Mechanism of Action Emt protein-tyrosine kinase inhibitors; Janus kinase 3 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Alopecia areata
  • Phase III Ulcerative colitis; Vitiligo
  • Phase II Chronic urticaria; Coeliac disease; Crohn's disease; Hidradenitis suppurativa; Type 1 diabetes mellitus
  • Discontinued Rheumatoid arthritis

Most Recent Events

  • 13 Nov 2025 Phase-II clinical trials in Hidradenitis suppurativa in USA (PO) (NCT07228390)
  • 05 Nov 2025 Pfizer plans a phase II trial for Hidradenitis Suppurativa(Treatment-experienced) in USA (PO) in November 2025 (NCT07228390)(EUCT2025-522705-37-00 )
  • 30 Oct 2025 Phase-II clinical trials in Chronic-urticaria (Treatment-experienced) in USA (PO) (NCT07219615)

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