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Ritlecitinib - Pfizer

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Drug Profile

Ritlecitinib - Pfizer

Alternative Names: LITFULO; Litfulo; PF 06651600; PF 6651600; Ritlecitinib tosilate - Pfizer; Ritlecitinib tosylate - Pfizer

Latest Information Update: 27 Oct 2025

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At a glance

  • Originator Pfizer
  • Developer National Institute of Diabetes and Digestive and Kidney Diseases; Pfizer
  • Class Amines; Anti-inflammatories; Antihyperglycaemics; Antirheumatics; Antiulcers; Heterocyclic bicyclo compounds; Ketones; Piperidines; Pyrimidines; Pyrroles; Skin disorder therapies; Small molecules
  • Mechanism of Action Emt protein-tyrosine kinase inhibitors; Janus kinase 3 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Alopecia areata
  • Phase III Ulcerative colitis; Vitiligo
  • Phase II Coeliac disease; Crohn's disease; Type 1 diabetes mellitus
  • Discontinued Rheumatoid arthritis

Most Recent Events

  • 24 Oct 2025 Pfizer plans a phase II trial for Chronic urticaria (Treatment-experienced) (PO) in October 2025 (NCT07219615)
  • 31 Jul 2025 Phase-III clinical trials in Alopecia areata (In children, Treatment-experienced) in Japan, USA (PO) (NCT07029711)
  • 15 Jul 2025 Pfizer terminates a phase II trial in Cutaneous T Cell Lymphomas in USA, due to no significant improvement in the disease as graded by the assessments (NCT05879458)

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