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Ritlecitinib - Pfizer

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Drug Profile

Ritlecitinib - Pfizer

Alternative Names: LITFULO; Litfulo; PF 06651600; PF 6651600; Ritlecitinib tosilate - Pfizer; Ritlecitinib tosylate - Pfizer

Latest Information Update: 19 Aug 2026

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At a glance

  • Originator Pfizer
  • Developer National Institute of Diabetes and Digestive and Kidney Diseases; Pfizer
  • Class Amines; Anti-inflammatories; Antihyperglycaemics; Antirheumatics; Antiulcers; Heterocyclic bicyclo compounds; Ketones; Piperidines; Pyrimidines; Pyrroles; Skin disorder therapies; Small molecules
  • Mechanism of Action Emt protein-tyrosine kinase inhibitors; Janus kinase 3 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Alopecia areata
  • Phase III Vitiligo
  • Phase II Chronic urticaria; Coeliac disease; Hidradenitis suppurativa; Type 1 diabetes mellitus
  • Discontinued Crohn's disease; Rheumatoid arthritis; Ulcerative colitis

Most Recent Events

  • 19 Aug 2026 Discontinued - Phase-II for Crohn's disease (Combination therapy, Treatment-experienced) in Australia (PO)
  • 31 Jul 2026 Pfizer plans a phase III trial for Alopecia areata (In adolescents, In adults, In the elderly) in USA (PO) (NCT07733765)
  • 30 Jul 2026 Pfizer initiates a phase III trial for Alopecia areata (In adolescents, In adults, In the elderly) in USA and Japan (PO) (NCT07733765)

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