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Peposertib - Merck KGaA

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Drug Profile

Peposertib - Merck KGaA

Alternative Names: M-3814; MSC-2490484A; Nedisertib

Latest Information Update: 15 Jul 2024

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At a glance

  • Originator Merck KGaA
  • Developer EMD Serono Research & Development Institute; M. D. Anderson Cancer Center; Merck KGaA; National Cancer Institute (USA); Telix Pharmaceuticals; University of Kentucky
  • Class Antineoplastics; Halogenated hydrocarbons; Morpholines; Pyridazines; Quinazolines; Small molecules
  • Mechanism of Action DNA-activated protein kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Pancreatic cancer; Rectal cancer; Small cell lung cancer
  • Phase I Solid tumours
  • Preclinical Neuroblastoma
  • No development reported Cancer; Chronic lymphocytic leukaemia; Glioblastoma; Neuroendocrine tumours

Most Recent Events

  • 31 May 2024 Adverse events data from a phase I/II trial in Pancreatic cancer presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)
  • 31 May 2024 Efficacy and adverse events data from a phase I trial in Glioblastoma presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)
  • 05 Apr 2024 Preclinical trials in Neuroblastoma in USA (PO)

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