Peposertib - Merck KGaA
Alternative Names: M-3814; MSC-2490484A; NedisertibLatest Information Update: 17 Dec 2024
At a glance
- Originator Merck KGaA
- Developer EMD Serono Research & Development Institute; M. D. Anderson Cancer Center; Merck KGaA; National Cancer Institute (USA); Telix Pharmaceuticals; University of Kentucky
- Class Antineoplastics; Halogenated hydrocarbons; Morpholines; Pyridazines; Quinazolines; Small molecules
- Mechanism of Action DNA-activated protein kinase inhibitors
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Phase I/II Cholangiocarcinoma; Gallbladder cancer; Pancreatic cancer; Rectal cancer; Small cell lung cancer; Solid tumours
- Preclinical Neuroblastoma
- No development reported Cancer; Chronic lymphocytic leukaemia; Glioblastoma; Neuroendocrine tumours
Most Recent Events
- 23 Oct 2024 Adverse events and efficacy data from phase I/II trial in Solid tumours presented at the 36th EORTC-NCI-AACR Symposium on molecular targets and cancer therapeutics (EORTC-NCI-AACR) (PO)
- 31 May 2024 Adverse events data from a phase I/II trial in Pancreatic cancer presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)
- 31 May 2024 Efficacy and adverse events data from a phase I trial in Glioblastoma presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)