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Evobrutinib - Merck Serono

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Drug Profile

Evobrutinib - Merck Serono

Alternative Names: M-2951; MSC-2364447; MSC2364447C

Latest Information Update: 22 Jul 2024

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At a glance

  • Originator Merck Serono
  • Developer EMD Serono; Merck Serono
  • Class Amines; Anti-inflammatories; Antirheumatics; Phenyl ethers; Piperidines; Pyrimidines; Small molecules
  • Mechanism of Action Agammaglobulinaemia tyrosine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Encephalomyelitis; Multiple sclerosis; Rheumatoid arthritis; Systemic lupus erythematosus

Most Recent Events

  • 22 Jul 2024 Discontinued - Phase-III for Multiple sclerosis (Treatment-experienced) in Germany, Georgia, France, Finland, Estonia, Croatia, Czech Republic, Colombia, Canada, Bulgaria, Bosnia-Herzegovina, Belgium, Australia, Austria, Argentina, Norway, Philippines, Moldova, Malaysia, Latvia, Belarus, USA, Greece, Lithuania, United Kingdom, Ukraine, Spain, Serbia, Serbia, Poland, Poland, South Korea, South Korea, Israel, Mexico, Mexico, Italy, Netherlands, Russia, Ukraine, Taiwan, India, Hungary, Turkey, Thailand, Switzerland, Sweden, Slovakia, Singapore, Romania, Portugal, Puerto Rico, South Africa, Saudi Arabia, Hong Kong (PO), before July 2024 (Merck Sereno pipeline, July 2024)
  • 22 Jul 2024 Discontinued - Preclinical for Encephalomyelitis in USA (PO), before July 2024 (Merck Sereno pipeline, July 2024)
  • 29 Apr 2024 EMD Serono and Merck terminate the phase III evolutionRMS 1 trial in Multiple sclerosis in USA, Ukraine, United Kingdom, Taiwan, Spain, Serbia, Russia, Poland, Netherlands, South Korea, Mexico, Italy, Israel, India, Hungary, Hong Kong, Germany, Georgia, France, Finland, Estonia, Croatia, Czech Republic, Colombia, Canada, Bulgaria, Bosnia-Herzegovina, Belgium, Australia, Austria, Argentina (PO), due to the results of EVOLUTION clinical trials, which showed that evobrutinib did not meet its primary endpoint (NCT04338022) (EudraCT2019-004972-20)

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