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Zenocutuzumab - Merus

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Drug Profile

Zenocutuzumab - Merus

Alternative Names: BIZENGRI; HER3 x HER2 Biclonics®; MCLA-128; Zeno; Zenocutuzomab - Merus; zenocutuzumab-zbco - Merus

Latest Information Update: 06 Jun 2025

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At a glance

  • Originator Merus
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; ERBB 2 receptor antagonists; ERBB-3 receptor antagonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Adenocarcinoma; Non-small cell lung cancer
  • Phase II HER2 positive breast cancer; Prostate cancer
  • Phase I/II Solid tumours
  • Preclinical Cancer

Most Recent Events

  • 20 May 2025 Merus completes an expanded access program for Solid tumour (Late stage disease, Metastatic disease, Second-line therapy or greater) (NCT04100694)
  • 09 Dec 2024 Preclinical trials in Cancer in Netherlands (Parenteral), before December 2024 (Merus pipeline, December 2024)
  • 04 Dec 2024 Updated efficacy data from the phase I/II eNRGy trial in Solid tumours released by Merus

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