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PAC 1

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Drug Profile

PAC 1

Alternative Names: Procaspase activating compound 1; VO-100

Latest Information Update: 17 Jun 2024

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At a glance

  • Originator Vanquish Oncology
  • Developer Genentech; Hoosier Cancer Research Network; University of Illinois at Chicago; Vanquish Oncology
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Apoptosis stimulants; Caspase 3 stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Uveal melanoma
  • Phase I Anaplastic astrocytoma; Glioblastoma; Lymphoma

Most Recent Events

  • 05 Apr 2024 PAC 1 is still in phase I trials for Anaplastic astrocytoma, Glioblastoma and Lymphoma (Monotherapy, Second-line therapy or greater, Late-stage disease, Combination therapy) in USA (PO), (NCT02355535)
  • 05 Apr 2024 Pharmacodynamics data from preclinical studies in Solid tumours at the 115th Annual Meeting of the American Association for Cancer Research (AACR-2024)
  • 28 Jun 2023 No recent reports of development identified for phase-I development in Anaplastic-astrocytoma(Combination therapy, Late-stage disease, Second-line therapy or greater) in USA (PO)

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