Drug Profile

Pemigatinib - Incyte Corporation

Alternative Names: Dabotan; IBI-375; INCB 54828; INCB-054828; Pemazyre

Latest Information Update: 26 Aug 2026

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At a glance

Originator Incyte Corporation
Developer Academic and Community Cancer Research United; Incyte Biosciences International; Incyte Corporation; Innovent Biologics; Knight Therapeutics; National Cancer Institute (USA)
Class Antineoplastics; Ethers; Fluorobenzenes; Morpholines; Pyridines; Pyrimidinones; Pyrroles; Small molecules
Mechanism of Action Type 1 fibroblast growth factor receptor antagonists; Type 3 fibroblast growth factor receptor antagonists; Type-2 fibroblast growth factor receptor antagonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Cholangiocarcinoma; Myeloproliferative disorders; Lymphoma
New Molecular Entity Yes

Marketed Cholangiocarcinoma
Registered Lymphoma; Myeloproliferative disorders
Phase II Adenosquamous carcinoma; Bladder cancer; Colorectal cancer; Endometrial cancer; Glioblastoma; Non-small cell lung cancer; Solid tumours; Urogenital cancer
Phase I/II Cancer

11 Aug 2026 Incyte Corporation terminates a phase III FIGHT-302 trial in Cholangiocarcinoma in Austria, Belgium, Finland, France, Germany, Ireland, Israel, Italy, Japan, Netherlands, Norway, Spain, Sweden, Switzerland, United Kingdom due to lack of enrollment resulting from a change in the standard of care (PO) (NCT03656536)
02 Jun 2026 Efficacy and adverse events data from a phase III trial in Cholangiocarcinoma presented at the 62nd Annual Meeting of the American Society of Clinical Oncology (ASCO-2026)
07 May 2026 Launched for Cholangiocarcinoma (Second-line therapy or greater, Late-stage disease) in Argentina (PO)

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