Research programme: menin-MLL inhibitors - Kura Oncology

Drug Profile

Research programme: menin-MLL inhibitors - Kura Oncology

Alternative Names: KO 381; KO 382; KO 539; MI 463; MI 503

Latest Information Update: 14 Dec 2017

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At a glance

  • Originator University of Michigan
  • Developer Kura Oncology; University of Michigan
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Menin inhibitors; Protein interaction domain and motif inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Acute biphenotypic leukaemia; Leukaemia

Most Recent Events

  • 12 Mar 2018 Kura Oncology plans to file an IND application with the US FDA by late 2018 or early 2019
  • 14 Dec 2017 KO 539 is still in preclinical trials for Leukaemia in USA (PO)
  • 01 Dec 2016 Pharmacodynamics data from preclinical trials in Leukaemia presented at the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics (EORTC 2016)
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