Research programme: mitochondria-derived peptides - CohBar

Drug Profile

Research programme: mitochondria-derived peptides - CohBar

Alternative Names: CB-4209; Humanin - CohBar; MBTs - CohBar; MDPs - CohBar; Mitochondria-based therapeutics - CohBar; MOTS-c; MOTS-c analog - CohBar; SHLP 2; SHLP 6; Small humanin-like peptides - CohBar

Latest Information Update: 23 Nov 2017

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At a glance

  • Originator Albert Einstein College of Medicine; University of Southern California
  • Developer Albert Einstein College of Medicine; CohBar; University of Southern California
  • Class Antihyperglycaemics; Antineoplastics; Cardiovascular therapies; Hepatoprotectants; Hormones; Neuroprotectants; Obesity therapies; Peptides
  • Mechanism of Action AMP activated protein kinase stimulants; Angiogenesis inhibitors; Apoptosis stimulants; Insulin receptor modulators; Lipolysis-inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Preclinical Non-alcoholic steatohepatitis; Obesity; Prostate cancer; Type 2 diabetes mellitus
  • Research Alzheimer's disease; Atherosclerosis; Cancer; Cerebral ischaemia; Myocardial ischaemia; Neurodegenerative disorders

Most Recent Events

  • 02 Apr 2018 CohBar plans a phase Ia/Ib trial for Obesity in mid-2018
  • 23 Nov 2017 Pharmacodynamics data from a preclinical studies in Nonalcoholic Steatohepatitis and Obesity presented at the at 68th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD- 2017)
  • 23 Oct 2017 Pharmacodynamic data from preclinical studies in Non-alcoholic steatohepatitis released by CohBar
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