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Bezuclastinib - Cogent Biosciences

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Drug Profile

Bezuclastinib - Cogent Biosciences

Alternative Names: CGT 9486; PLX 9486

Latest Information Update: 13 Dec 2024

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At a glance

  • Originator Plexxikon
  • Developer Cogent Biosciences; Plexxikon
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Proto-oncogene protein c-kit inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastrointestinal stromal tumours; Systemic mastocytosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Gastrointestinal stromal tumours
  • Phase II Systemic mastocytosis
  • Phase I/II Solid tumours

Most Recent Events

  • 09 Dec 2024 Pharmacodynamics, efficacy, and adverse events data from the phase II SUMMIT trial in Systemic mastocytosis released by Cogent Biosciences
  • 08 Dec 2024 Updated adverse events and efficacy data from a phase II APEX trial in Systemic mastocytosis released by Cogent Biosciences
  • 03 Sep 2024 Cogent Biosciences announces intention to submit NDA to regulatory body for Gastrointestinal stromal tumours and Systemic mastocytosis

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