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APN 401

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Drug Profile

APN 401

Alternative Names: APN-401; siRNA-transfected PBMC APN401; siRNA-transfected peripheral blood mononuclear cells - Apeiron

Latest Information Update: 04 Jul 2025

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At a glance

  • Originator Apeiron Biologics
  • Developer Apeiron Biologics; Comprehensive Cancer Center of Wake Forest University; National Cancer Institute (USA)
  • Class Antineoplastics; Cell therapies; Gene therapies; Immunotherapies; Small interfering RNA
  • Mechanism of Action Cell replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase I Solid tumours

Most Recent Events

  • 30 Jun 2025 Efficacy and adverse events data from a phase Ib PALINDROME trial in Solid tumours released by invIOs
  • 26 Dec 2024 Phase-I development is ongoing in USA and Austria
  • 01 Oct 2024 InvIOs completes phase-I clinical trials in Solid tumours (Late-stage disease) in Austria (IV) (NCT06172894)

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