Drug Profile


Alternative Names: AKCEA-APO(a)-LRx; IONIS-681257; IONIS-APO(a)-LRx; IONIS-APO-LRx; ISIS 681257; ISIS-APO(a)-LRx; ISIS-APOALRx

Latest Information Update: 02 May 2018

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At a glance

  • Originator Isis Pharmaceuticals
  • Developer Akcea Therapeutics; Ionis Pharmaceuticals
  • Class Antihyperlipidaemics; Antisense oligonucleotides
  • Mechanism of Action Apolipoprotein A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Hyperlipoproteinaemias

Most Recent Events

  • 20 Mar 2018 Akcea Therapeutics and Ionis Pharmaceuticals initiate a phase I adaptive pharmacokinetic single-dose trial in USA (NCT03506854)
  • 18 Mar 2018 Akcea Therapeutics completes a phase I trial for Hyperlipoproteinaemia (In volunteers) in Canada (SC) (NCT03392051)
  • 25 Feb 2018 Akcea Therapeutics completes a phase I drug-drug interaction trial for Hyperlipoproteinaemia (In volunteers, In adolescents, In adults) in Canada (SC) (NCT03426033)
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