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ISTH 0036

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Drug Profile

ISTH 0036

Alternative Names: ISTH-0036; TGF-Β2 isoform specific antisense oligonucleotide - Isarna Therapeutics

Latest Information Update: 29 Jul 2023

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At a glance

  • Originator Isarna Therapeutics
  • Class Antiglaucomas; Antisense oligonucleotides; Eye disorder therapies
  • Mechanism of Action Gene silencing; Transforming growth factor beta2 expression inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Scars
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Diabetic macular oedema; Wet age-related macular degeneration
  • Phase I Open-angle glaucoma
  • Preclinical Cancer; Dry age-related macular degeneration

Most Recent Events

  • 20 Jul 2023 Preclinical trials in Cancer in Germany (Parenteral) (Isarna Therapeutics pipeline; July 2023)
  • 16 May 2023 ISTH 0036 is still in phase-I clinical trial in Open angle glaucoma in Germany (Intravitreous) (Isarna Therapeutics pipeline, May 2023)
  • 16 May 2023 Preclinical trials in Dry age-related macular degeneration in Germany, prior to May 2023 (unspecified) (Isarna Therapeutics pipeline, May 2023)

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