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ISTH 0036

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Drug Profile

ISTH 0036

Alternative Names: ISTH-0036; TGF-Β2 isoform specific antisense oligonucleotide - Isarna Therapeutics

Latest Information Update: 28 May 2025

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At a glance

  • Originator Isarna Therapeutics
  • Class Antiglaucomas; Antisense oligonucleotides; Eye disorder therapies
  • Mechanism of Action Gene silencing; Transforming growth factor beta2 expression inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Scars
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Diabetic macular oedema; Wet age-related macular degeneration
  • Preclinical Cancer; Dry age-related macular degeneration
  • No development reported Open-angle glaucoma

Most Recent Events

  • 28 May 2025 No recent reports of development identified for phase-I development in Open-angle-glaucoma in Germany (Intravitreous, Injection)
  • 07 May 2025 Adverse events and efficacy data from a phase II BETTER trial in Wet age-related macular degeneration released by Isarna Therapeutics
  • 07 May 2025 Isarna Therapeutics plans a phase IIb/III trial for Wet age-related macular degeneration in EU and USA

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