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BMS 986158

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Drug Profile

BMS 986158

Alternative Names: BET inhibitor - Bristol-Myers Squibb; BMS-986158

Latest Information Update: 12 Feb 2025

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At a glance

  • Originator Bristol-Myers Squibb
  • Class Antineoplastics; Indoles; Propanols; Pyridines; Small molecules; Triazoles
  • Mechanism of Action Bromodomain and extraterminal domain protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Solid tumours
  • Phase I/II Multiple myeloma; Myelofibrosis

Most Recent Events

  • 07 Dec 2024 Updated efficacy and adverse event data from a phase I/II trial in Multiple myeloma presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2024)
  • 05 Apr 2024 Pharmacodynamics data from a preclinical studies in Solid tumours presented at the 115th Annual Meeting of the American Association for Cancer Research (AACR-2024)
  • 27 Mar 2024 Efficacy and pharmacokinetics data from a phase I/II in Myelofibrosis presented at the 125th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT-2024)

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