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Ivarmacitinib - Arcutis Biotherapeutics/Jiangsu HengRui Medicine

Drug Profile

Ivarmacitinib - Arcutis Biotherapeutics/Jiangsu HengRui Medicine

Alternative Names: ARQ-252; ARQ-255; Ivarmacitinib sulfate; SHR-0302

Latest Information Update: 09 Jan 2026

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At a glance

  • Originator Jiangsu Hengrui Medicine Co.
  • Developer Arcutis Biotherapeutics; Jiangsu Hengrui Medicine Co.; Reistone Biopharma
  • Class 2 ring heterocyclic compounds; Amides; Amines; Anti-inflammatories; Antineoplastics; Antipsoriatics; Antirheumatics; Cyclopentanes; Heterocyclic bicyclo compounds; Methyl ethers; Pyrimidines; Pyrroles; Pyrrolidines; Skin disorder therapies; Small molecules; Sulfates; Thiadiazoles
  • Mechanism of Action Janus kinase 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Alopecia areata; Ankylosing spondylitis; Atopic dermatitis; Non-radiographic axial spondyloarthritis; Psoriatic arthritis; Rheumatoid arthritis; Ulcerative colitis; Vitiligo
  • Phase II Crohn's disease; Peripheral T-cell lymphoma
  • Phase I Graft-versus-host disease
  • Preclinical Eczema

Most Recent Events

  • 18 Dec 2025 Launched for Alopecia areata in China (PO) before December 2025 (Jiangsu HengRui Medicine pipeline, December 2025)
  • 18 Dec 2025 Launched for Non-radiographic axial spondyloarthritis (Treatment-resistant) in China (PO) before December 2025 (Jiangsu HengRui Medicine pipeline, December 2025)
  • 18 Dec 2025 Launched for Ulcerative colitis in China (PO) before December 2025 (Jiangsu HengRui Medicine pipeline, December 2025)

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