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SHR 0302

Drug Profile

SHR 0302

Alternative Names: ARQ 252 active ingredient - Jiangsu Hengrui Medicine; SHR-0302

Latest Information Update: 08 Feb 2021

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At a glance

  • Originator Jiangsu Hengrui Medicine Co.
  • Developer Jiangsu Hengrui Medicine Co.; Reistone Biopharma
  • Class 2 ring heterocyclic compounds; Amides; Amines; Anti-inflammatories; Antirheumatics; Cyclopentanes; Pyrimidines; Pyrroles; Skin disorder therapies; Small molecules; Thiadiazoles
  • Mechanism of Action Janus kinase 1 inhibitors; STAT3 transcription factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Rheumatoid arthritis
  • Phase II/III Ankylosing spondylitis; Atopic dermatitis
  • Phase II Alopecia areata; Crohn's disease; Ulcerative colitis
  • Research Systemic lupus erythematosus

Most Recent Events

  • 04 Feb 2021 Efficacy and adverse events data from a phase II AMBER2 trial in ulcerative colitis released by Reistone Biopharma
  • 04 Feb 2021 Reistone Biopharma completes a phase II AMBER2 trial in Ulcerative colitis in US, China, Poland, Puerto Rico and Ukraine (NCT03675477) (EudraCT2018-003364-31)
  • 04 Feb 2021 Reistone Biopharma plans a phase III trial for ulcerative colitis in 2021
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