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Ivarmacitinib - Arcutis Biotherapeutics/Reistone Biopharma

Drug Profile

Ivarmacitinib - Arcutis Biotherapeutics/Reistone Biopharma

Alternative Names: ARQ 252 active ingredient - Jiangsu Hengrui Medicine; Ivarmacitinib sulfate - Arcutis Biotherapeutics/Reistone Biopharma; SHR-0302; SHR0302 base

Latest Information Update: 20 Jun 2022

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At a glance

  • Originator Jiangsu Hengrui Medicine Co.
  • Developer Jiangsu Hengrui Medicine Co.; Reistone Biopharma
  • Class 2 ring heterocyclic compounds; Amides; Amines; Anti-inflammatories; Antirheumatics; Cyclopentanes; Pyrimidines; Pyrroles; Skin disorder therapies; Small molecules; Thiadiazoles
  • Mechanism of Action Janus kinase 1 inhibitors; STAT3 transcription factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Atopic dermatitis; Psoriatic arthritis; Rheumatoid arthritis; Ulcerative colitis
  • Phase II/III Ankylosing spondylitis; Vitiligo
  • Phase II Alopecia areata; Crohn's disease
  • Phase I Liver disorders
  • Research Systemic lupus erythematosus

Most Recent Events

  • 07 Jun 2022 Jiangsu HengRui Medicine plans a pharmacokinetic phase I trial in Rheumatoid arthritis (In volunteers, Combination therapy, Monotherapy) (PO, Tablet), in June 2022 (NCT05404724)
  • 10 May 2022 Jiangsu HengRui Medicine plans a phase III drug-drug interaction trial in rheumatoid arthritis (In volunteers) in June 2022 (PO, Tablet) (NCT05392127)
  • 03 May 2022 Phase-III clinical trials in Ulcerative colitis (In adults, In the elderly) in USA, China, Ukraine and Georgia (PO) (Jiangsu Hengrui Medicine pipeline, May 2022) (NCT05181137)
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