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Mitazalimab - Alligator Bioscience

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Drug Profile

Mitazalimab - Alligator Bioscience

Alternative Names: ADC 1013; JNJ 7107; JNJ-64457107; Vanalimab

Latest Information Update: 04 Mar 2026

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At a glance

  • Originator Alligator Bioscience
  • Developer Alligator Bioscience; Erasmus MC; Janssen Biotech; Scandion Oncology; University of Pennsylvania
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; CD40 antigen stimulants; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Mouth disorders; Pancreatic cancer
  • No development reported Cancer; Solid tumours

Most Recent Events

  • 27 Feb 2026 UNICANCER plans a phase-II/III CROCOBIL trial for Cholangiocarcinoma (Combination therapy, Late-stage disease, Metastatic disease, Unresectable/Inoperable, Second-line therapy or greater) in France (IV, infusion) in July 2026 (NCT07437287)
  • 18 Feb 2026 Mitazalimab is still in phase I trials for Pancreatic cancer (Combination therapy, Metastatic disease, Second-line therapy or greater) in Netherlands (NCT05650918)
  • 01 Dec 2025 Efficacy and immunogenicity data from the phase I REACtiVe-2 trial in Pancreatic cancer released by Alligator Bioscience

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