RT 100

Drug Profile

RT 100

Alternative Names: Ad5-AC6; Ad5.hAC6; Adenylate cyclase gene therapy - Renova; RT100

Latest Information Update: 19 Dec 2017

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At a glance

  • Originator Renova Therapeutics
  • Class Gene therapies
  • Mechanism of Action Adenylate cyclase expression stimulants; Gene transference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase II Heart failure

Most Recent Events

  • 19 Dec 2017 RT 100 receives Fast Track designation for Heart failure [Intracoronary] in USA
  • 14 Dec 2017 Renova Therapeutics plans the phase III FLOURISH (Heart Failure with Reduced Left Ventricular Ejection Fraction: One-time Gene Transfer Using RT-100 – Intracoronary Administration of Adenovirus 5 encoding Human AC6) trial for Heart failure in USA in first quarter of 2018 (NCT03360448)
  • 04 Aug 2017 RT 100 is still in phase II development for Heart failure in USA (Renova Therapeutics, August 2017)
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