Leucine/metformin/sildenafil - NuSirt Biopharma

Drug Profile

Leucine/metformin/sildenafil - NuSirt Biopharma

Alternative Names: Leu-Met-Sil; Leucine/sildenafil/metformin; Metformin/leucine/sildenafil; Metformin/sildenafil/leucine; NS-0200; Sildenafil/leucine/metformin; Sildenafil/metformin/leucine

Latest Information Update: 16 May 2018

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At a glance

  • Originator NuSirt Biopharma
  • Class Biguanides; Branched-chain amino acids; Essential amino acids; Small molecules
  • Mechanism of Action AMP activated protein kinase stimulants; Gluconeogenesis inhibitors; SIRT1 protein stimulants; Sirtuin modulators; Type 5 cyclic nucleotide phosphodiesterase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase II Non-alcoholic fatty liver disease; Obesity
  • Preclinical Non-alcoholic steatohepatitis

Most Recent Events

  • 21 Apr 2018 Pharmacodynamics data from a preclinical study in Non-alcoholic fatty liver disease presented at The International Liver Congress 2018 (ILC-2018)
  • 08 Jan 2018 Phase-II clinical trials in Obesity in USA (PO) (NCT03364335)
  • 14 Dec 2017 NuSirt Biopharma plans a phase II trial for Obesity in January 2018 (PO) (NCT03364335)
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