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Lademirsen - Novartis

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Drug Profile

Lademirsen - Novartis

Alternative Names: Lademirsen sodium; RG 012; RG 456070; SAR 339375

Latest Information Update: 01 Jul 2025

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At a glance

  • Originator Regulus Therapeutics; Sanofi
  • Developer Novartis; Regulus Therapeutics
  • Class Antisense oligoribonucleotides; MicroRNAs; Urologics
  • Mechanism of Action MicroRNA inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hereditary nephritis
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Hereditary nephritis

Most Recent Events

  • 25 Jun 2025 Regulus Therapeutics has been acquired and merged into Novartis
  • 07 Apr 2023 Sanofi terminates its R & D agreement with Regulus Therapeutics for Lademirsen
  • 28 Jul 2022 Discontinued - Phase-II for Hereditary nephritis in USA, Spain, Germany, France, China, Canada, Australia, United Kingdom (SC) as of July 2022

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