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Nomacopan - Akari Therapeutics

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Drug Profile

Nomacopan - Akari Therapeutics

Alternative Names: Coversin; EV 576; PAS-coversin; rEV 576; rVA576

Latest Information Update: 21 Jan 2020

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At a glance

  • Originator Evolutec
  • Developer Akari Therapeutics; Evolutec
  • Class Anti-inflammatories; Antiasthmatics; Antirheumatics; Eye disorder therapies; Recombinant proteins; Skin disorder therapies
  • Mechanism of Action Complement C5a inhibitors; Leukotriene B4 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Paroxysmal nocturnal haemoglobinuria; Thrombotic microangiopathy; Guillain-Barre syndrome; Bullous pemphigoid
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Haemolytic uraemic syndrome; Paroxysmal nocturnal haemoglobinuria
  • Phase II Bullous pemphigoid; Thrombotic microangiopathy
  • Phase I/II Keratoconjunctivitis
  • Preclinical Rheumatoid arthritis; Uveitis
  • No development reported Guillain-Barre syndrome; Myasthenia gravis; Sjogren's syndrome
  • Discontinued Asthma; Autoimmune disorders; Inflammation

Most Recent Events

  • 10 Jan 2020 AKARI Therapeutics temporarily suspends the phase III CAPSTONE trial for Paroxysmal nocturnal hemoglobinuria in Kazakhstan; Lithuania and Sri Lanka (NCT03588026)
  • 10 Jan 2020 Interim efficacy and adverse events data from the phase III CAPSTONE trial for Paroxysmal nocturnal haemoglobinuria released by Akari Therapeutics
  • 10 Jan 2020 Updated efficacy results from the phase II COBALT trial for Paroxysmal nocturnal haemoglobinuria released by Akari Therapeutics
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