Drug Profile

Nomacopan - Akari Therapeutics

Alternative Names: Coversin; EV 576; long-acting PAS-nomacopan; PAS-coversin; PAS-nomacopan; rEV 576; rVA576

Latest Information Update: 28 Mar 2025

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At a glance

Originator Evolutec
Developer Akari Therapeutics; Evolutec; US Army Institute of Surgical Research
Class Anti-inflammatories; Antiasthmatics; Antirheumatics; Antithrombotics; Antivirals; Eye disorder therapies; Recombinant proteins; Skin disorder therapies
Mechanism of Action Complement C5a inhibitors; Leukotriene B4 inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Paroxysmal nocturnal haemoglobinuria; Thrombotic microangiopathy; Guillain-Barre syndrome; Bullous pemphigoid; Thrombotic microangiopathies
New Molecular Entity Yes
Available For Licensing Yes

Phase III Haemolytic uraemic syndrome
Phase I/II COVID-19 pneumonia; Keratoconjunctivitis
Preclinical Asthma; Dry age-related macular degeneration; Haemorrhagic shock; Subarachnoid haemorrhage; Traumatic brain injuries
Suspended Thrombotic microangiopathy
No development reported Guillain-Barre syndrome; Myasthenia gravis; Rheumatoid arthritis; Sjogren's syndrome; Uveitis; Wet age-related macular degeneration
Discontinued Autoimmune disorders; Bullous pemphigoid; Inflammation; Paroxysmal nocturnal haemoglobinuria

28 Mar 2025 No recent reports of development identified for preclinical development in Wet age-related macular degeneration in United Kingdom (Intravitreous)
28 Jan 2025 No recent reports of development identified for preclinical development in Uveitis in United Kingdom (Intravitreous)
19 Aug 2024 Nomacopan - Akari Therapeutics is available for licensing as of 19 Aug 2024. www.akaritx.com 9423868

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