Nomacopan - Akari Therapeutics

Drug Profile

Nomacopan - Akari Therapeutics

Alternative Names: Coversin; EV 576; PAS-coversin; rEV 576

Latest Information Update: 27 Jul 2018

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At a glance

  • Originator Evolutec
  • Developer Akari Therapeutics; Evolutec
  • Class Anti-inflammatories; Recombinant proteins
  • Mechanism of Action Complement C5a inhibitors; Leukotriene B4 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Paroxysmal nocturnal haemoglobinuria; Guillain-Barre syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Haemolytic uraemic syndrome; Paroxysmal nocturnal haemoglobinuria
  • Phase II Bullous pemphigoid
  • Preclinical Conjunctivitis; Myasthenia gravis; Sjogren's syndrome
  • No development reported Guillain-Barre syndrome
  • Discontinued Asthma; Autoimmune disorders; Inflammation

Most Recent Events

  • 20 Jun 2018 Phase-III clinical trials in Paroxysmal nocturnal haemoglobinuria in Lithuania (SC) (NCT03588026)
  • 14 May 2018 Phase-II clinical trials in Paroxysmal nocturnal haemoglobinuria in Argentina (SC) (NCT03427060)
  • 07 May 2018 Phase-IIa clinical trials in Bullous pemphigoid in Netherlands (SC) (EudraCT2017-002836-18)
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