Coversin - Akari Therapeutics

Drug Profile

Coversin - Akari Therapeutics

Alternative Names: Coversin; EV 576; PAS-coversin; rEV 576

Latest Information Update: 26 Mar 2018

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At a glance

  • Originator Evolutec
  • Developer Akari Therapeutics; Evolutec
  • Class Anti-inflammatories; Recombinant proteins
  • Mechanism of Action Complement C5a inhibitors; Leukotriene B4 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Paroxysmal nocturnal haemoglobinuria; Guillain-Barre syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Haemolytic uraemic syndrome; Paroxysmal nocturnal haemoglobinuria
  • Preclinical Bullous pemphigoid; Conjunctivitis; Myasthenia gravis; Sjogren's syndrome
  • No development reported Guillain-Barre syndrome
  • Discontinued Asthma; Autoimmune disorders; Inflammation

Most Recent Events

  • 21 Mar 2018 Akari Therapeutics receives regulatory approval to initiate phase III CAPSTONE trial in Paroxysmal nocturnal haemoglobinuria in Europe
  • 07 Feb 2018 Akari Therapeutics completes the phase II COBALT trial in Paroxysmal nocturnal haemoglobinuria in United Kingdom (SC)
  • 06 Feb 2018 Akari Therapeutics plans a phase II trial for Bullous Pemphigoid in first half of 2018
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