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Mosunetuzumab - Genentech

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Drug Profile

Mosunetuzumab - Genentech

Alternative Names: Anti-CD20/CD3 T-cell dependent bispecific antibody; BTCT 4465A; CD20-TBD; CD20xCD3 T-cell engaging bispecific antibody; Lunsumio; mosunetuzumab-axgb; RG7828; RO7030816

Latest Information Update: 25 Jun 2025

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At a glance

  • Originator Genentech
  • Developer Chugai Pharmaceutical; Genentech; Roche
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Follicular lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Follicular lymphoma
  • Phase III Non-Hodgkin's lymphoma
  • Phase II Diffuse large B cell lymphoma; Marginal zone B-cell lymphoma
  • Phase I/II Chronic lymphocytic leukaemia
  • Phase I B-cell lymphoma; Systemic lupus erythematosus

Most Recent Events

  • 20 Jun 2025 Efficacy and adverse events data from the phase III SUNMO trial in Non-Hodgkin lymphoma released by Roche
  • 28 Apr 2025 No recent reports of development identified for phase-I development in Chronic-lymphocytic-leukaemia(Second-line therapy or greater) in Italy (SC, Injection)
  • 02 Apr 2025 University of Washington in collaboration with Genentech completes a phase II trial for Non-Hodgkin lymphoma (Monotherapy, In combination therapy) in the US (SC) (NCT05169658)

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