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Mosunetuzumab - Genentech

Drug Profile

Mosunetuzumab - Genentech

Alternative Names: Anti-CD20/CD3 T-cell dependent bispecific antibody; BTCT 4465A; CD20-TBD; CD20xCD3 T-cell engaging bispecific antibody; Lunsumio; mosunetuzumab-axgb; RG7828; RO7030816

Latest Information Update: 13 Feb 2024

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At a glance

  • Originator Genentech
  • Developer Genentech; Roche
  • Class Antineoplastics; Bispecific antibodies; Immunotherapies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Follicular lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Follicular lymphoma
  • Phase III Diffuse large B cell lymphoma; Non-Hodgkin's lymphoma
  • Phase II Marginal zone B-cell lymphoma
  • Phase I/II Chronic lymphocytic leukaemia
  • Phase I B-cell lymphoma; Systemic lupus erythematosus

Most Recent Events

  • 13 Feb 2024 Efficacy and adverse event data from a phase I expanded cohort trial in Follicular lymphoma released by Chugai Pharamceuticals
  • 09 Feb 2024 Chugai Pharamceuticals completes a phase I expanded cohort trial in Follicular lymphoma (Second-line therapy or greater, Refractory disease) in Japan (JapicCTI-183857)
  • 12 Dec 2023 Phase-II clinical trials in Non-Hodgkin's lymphoma (Monotherapy) in Puerto Rico (SC) (NCT05207670)
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