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Oleclumab - AstraZeneca

Drug Profile

Oleclumab - AstraZeneca

Alternative Names: Anti-CD73 MAb; Anti-CD73 monoclonal antibody; MEDI-9447

Latest Information Update: 22 Jun 2024

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At a glance

  • Originator MedImmune
  • Developer AstraZeneca; European Network of Gynaecological Oncological Trial Groups; Jules Bordet Institute; M. D. Anderson Cancer Center; MedImmune; National Cancer Institute (USA)
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action 5-nucleotidase inhibitors; Antibody-dependent cell cytotoxicity; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-small cell lung cancer
  • Phase II Breast cancer; Ovarian cancer; Pancreatic cancer; Prostate cancer; Sarcoma
  • Phase I/II Colorectal cancer
  • No development reported Bladder cancer; Solid tumours

Most Recent Events

  • 05 Apr 2024 Pharmacodynamics data from the phase II NeoCOAST trial in Non-small cell lung cancer presented at the 115th Annual Meeting of the American Association for Cancer Research (AACR-2024)
  • 04 Oct 2023 University Health Network plans a phase II trial for Pancreatic Cancer (IV) in October 2023 (NCT06060405)
  • 18 Jul 2023 MedImmune completes the phase II COAST trial for Non-small cell lung cancer (Combination therapy, Monotherapy, Second line therapy or greater, Late stage disease, Unresectable/Inoperable) in US, Canada, France, Hong Kong, Italy, Poland, Portugal, Spain and Taiwan (IV) (NCT03822351)
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