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Oleclumab - AstraZeneca

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Drug Profile

Oleclumab - AstraZeneca

Alternative Names: Anti-CD73 mAb - AstraZeneca; Anti-CD73 monoclonal antibody - AstraZeneca; MEDI-9447

Latest Information Update: 30 Sep 2024

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At a glance

  • Originator MedImmune
  • Developer AstraZeneca; MedImmune
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action 5-nucleotidase inhibitors; Antibody-dependent cell cytotoxicity; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-small cell lung cancer
  • Phase II Breast cancer; Pancreatic cancer; Sarcoma
  • Phase I Solid tumours
  • Discontinued Bladder cancer; Colorectal cancer; Ovarian cancer; Prostate cancer

Most Recent Events

  • 19 Sep 2024 AstraZeneca plans a phase II study for Non small cell lung cancer (Inoperable/Unresectable, Late-stage disease, Combination therapy) in Russia (IV, Infusion) (NCT06606847)
  • 13 Sep 2024 Efficacy and adverse events data from phase-II clinical trials in Breast cancer presented at the 49th European Society for Medical Oncology Congress (ESMO-2024)
  • 07 Sep 2024 Efficacy and adverse events data from a phase II NeoCOAST 2 trial in Non-small lung cancer presented at the 25th World Conference on Lung Cancer (WCLC-2024)

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