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Tropifexor - Novartis

Drug Profile

Tropifexor - Novartis

Alternative Names: LJN-452; NVP-LJN452-NXA

Latest Information Update: 28 Jun 2023

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At a glance

  • Originator Novartis
  • Developer Allergan; Novartis
  • Class Anti-inflammatories; Antifibrotics; Benzothiazoles; Hepatoprotectants; Oxazoles; Small molecules
  • Mechanism of Action Farnesoid X-activated receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Hepatic fibrosis; Non-alcoholic steatohepatitis; Primary bile acid malabsorption; Primary biliary cirrhosis
  • No development reported Liver disorders

Most Recent Events

  • 28 Jun 2023 No recent reports of development identified for phase-I development in Liver-disorders in USA
  • 21 Jun 2023 Efficacy data from the phase II FLIGHT-FXR trial in Non-alcoholic steatohepatitis presented at the 72nd European Association for the Study of the Liver Congress (EASL-2023)
  • 15 Jun 2023 Efficacy data from a phase IIb TANDEM trial in Non-alcoholic steatohepatitis and and liver fibrosis released by Novartis
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