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Spesolimab - Boehringer Ingelheim

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Drug Profile

Spesolimab - Boehringer Ingelheim

Alternative Names: BI 655130; Spesolimab-sbzo; SPEVIGO

Latest Information Update: 24 Dec 2025

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At a glance

  • Originator Boehringer Ingelheim
  • Class Anti-inflammatories; Antipsoriatics; Monoclonal antibodies; Skin disorder therapies
  • Mechanism of Action Interleukin 36 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Generalised pustular psoriasis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Generalised pustular psoriasis
  • Phase III Pyoderma gangrenosum
  • Phase II/III Hidradenitis suppurativa; Netherton Syndrome; Ulcerative colitis
  • Phase II Crohn's disease; Palmoplantar pustulosis
  • Discontinued Atopic dermatitis

Most Recent Events

  • 12 Dec 2025 Boehringer Ingelheim terminated the phase-II/III EvasayilTM trial in Netherton-Syndrome (In the elderly, In children, In adolescents, In adults) in USA, United Kingdom, Switzerland, Portugal, Netherlands, Malaysia, Japan, Italy, Israel, Germany, France, China, Bulgaria, Australia (IV) due to sponsor's decision (NCT05856526)
  • 01 Oct 2025 LEO Pharma completes worldwide licensing deal with Boehringer Ingelheim for spesolimab
  • 16 Jul 2025 Launched for Generalised pustular psoriasis (In adults, In adolescents, In the elderly) in United Kingdom (IV)

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