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Spesolimab - Boehringer Ingelheim

Drug Profile

Spesolimab - Boehringer Ingelheim

Alternative Names: BI 655130; Spesolimab-sbzo; SPEVIGO

Latest Information Update: 16 May 2025

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At a glance

  • Originator Boehringer Ingelheim
  • Class Anti-inflammatories; Antipsoriatics; Monoclonal antibodies; Skin disorder therapies
  • Mechanism of Action Interleukin 36 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Generalised pustular psoriasis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Generalised pustular psoriasis
  • Phase III Pyoderma gangrenosum
  • Phase II/III Hidradenitis suppurativa; Netherton Syndrome; Ulcerative colitis
  • Phase II Crohn's disease; Palmoplantar pustulosis
  • Discontinued Atopic dermatitis

Most Recent Events

  • 11 Apr 2025 Boehringer Ingelheim completes a phase II/III Lunsayil LTE trial in Hidradenitis suppurativa in Canada, Singapore, Malaysia, Lithuania, South Korea, Japan, Bulgaria, Argentina, Spain, Poland, Germany, France, Australia, USA (SC) (NCT06241573)
  • 05 Feb 2025 Launched for Generalised pustular psoriasis (In adults, In adolescents, In children) in Canada (IV)
  • 05 Feb 2025 Launched for Generalised pustular psoriasis (In adults, In adolescents, In children, Prevention) in Canada (SC)

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