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Trospium chloride/xanomeline - Karuna Therapeutics

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Drug Profile

Trospium chloride/xanomeline - Karuna Therapeutics

Alternative Names: BMS-986510; COBENFY; Karuna-Xanomeline-Trospium - Karuna Therapeutics; KarXT - Karuna Therapeutics; Trospium chloride/LY-246708 - Karuna Therapeutics; Trospium chloride/xanomeline tartrate - Karuna Therapeutics; Xanomeline tartrate/ trospium chloride - Karuna Therapeutics; Xanomeline/trospium chloride - Karuna Therapeutics

Latest Information Update: 09 Sep 2026

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At a glance

  • Originator PureTech Health
  • Developer Bristol-Myers Squibb; Karuna Therapeutics; ZAI Lab
  • Class Analgesics; Antidementias; Antipsychotics; Antispasmodics; Benzhydryl compounds; Benzilates; Esters; Mood stabilisers; Nortropanes; Pyridines; Small molecules; Spiro compounds; Thiadiazoles; Urologics
  • Mechanism of Action Muscarinic M1 receptor agonists; Muscarinic M4 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Schizophrenia
  • Phase III Agitation; Alzheimer's disease; Autism spectrum disorder; Bipolar disorders; Psychotic disorders
  • Discontinued Pain

Most Recent Events

  • 30 Jun 2026 Launched for Schizophrenia in China (PO)
  • 30 Jun 2026 Karuna Therapeutics plans a phase III trial for Schizophrenia(Treatment experienced) in Argentina, Bulgaria, Czech Republic, Denmark, Poland, Romania, Spain, United Kingdom and USA (PO) in September 2026(NCT07686263)(U1111-1327-7599)(EUCT2025-523664-20)
  • 25 Jun 2026 Karuna Therapeutics completes a phase I trial (In volunteers) in USA (PO, Capsule) (NCT07118215)

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