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Trospium chloride/xanomeline - Karuna Therapeutics

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Drug Profile

Trospium chloride/xanomeline - Karuna Therapeutics

Alternative Names: BMS-986510; COBENFY; Karuna-Xanomeline-Trospium - Karuna Therapeutics; KarXT - Karuna Therapeutics; Trospium chloride/LY-246708 - Karuna Therapeutics; Trospium chloride/xanomeline tartrate - Karuna Therapeutics; Xanomeline tartrate/ trospium chloride - Karuna Therapeutics; Xanomeline/trospium chloride - Karuna Therapeutics

Latest Information Update: 05 Sep 2025

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At a glance

  • Originator PureTech Health
  • Developer Karuna Therapeutics; ZAI Lab
  • Class Analgesics; Antidementias; Antipsychotics; Antispasmodics; Benzhydryl compounds; Benzilates; Esters; Mood stabilisers; Nortropanes; Pyridines; Small molecules; Spiro compounds; Thiadiazoles; Urologics
  • Mechanism of Action Muscarinic M1 receptor agonists; Muscarinic M4 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Schizophrenia
  • Phase III Alzheimer's disease; Bipolar disorders; Psychotic disorders
  • Discontinued Pain

Most Recent Events

  • 05 Sep 2025 Bristol-Myers Squibb plans a phase-III trial for Manic episodes (Adjunctive treatment, In adults) in Denmark, Israel, Italy, Poland, Romania and United States (PO)(NCT07140913),
  • 12 Aug 2025 Karuna Therapeutics plans a phase I pharmacokinetic trial (In volunteers) in September 2025 (NCT07118215)
  • 25 Jul 2025 Bristol-Myers Squibb initiates the phase III ADAGIO-1 trial for Alzheimer's disease (Combination therapy) in the US (PO, Capsule) (NCT07011732)

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