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Trospium chloride/xanomeline - Karuna Therapeutics

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Drug Profile

Trospium chloride/xanomeline - Karuna Therapeutics

Alternative Names: BMS-986510; COBENFY; Karuna-Xanomeline-Trospium - Karuna Therapeutics; KarXT - Karuna Therapeutics; Trospium chloride/LY-246708 - Karuna Therapeutics; Trospium chloride/xanomeline tartrate - Karuna Therapeutics; Xanomeline tartrate/ trospium chloride - Karuna Therapeutics; Xanomeline/trospium chloride - Karuna Therapeutics

Latest Information Update: 26 Feb 2026

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At a glance

  • Originator PureTech Health
  • Developer Karuna Therapeutics; ZAI Lab
  • Class Analgesics; Antidementias; Antipsychotics; Antispasmodics; Benzhydryl compounds; Benzilates; Esters; Mood stabilisers; Nortropanes; Pyridines; Small molecules; Spiro compounds; Thiadiazoles; Urologics
  • Mechanism of Action Muscarinic M1 receptor agonists; Muscarinic M4 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Schizophrenia
  • Phase III Alzheimer's disease; Bipolar disorders; Psychotic disorders
  • Discontinued Pain

Most Recent Events

  • 20 Feb 2026 Karuna Therapeutics plans to initiate a phase III trial for Schizophrenia (In adolescents)and Autism-spectrum-disorder (In children, In adolescents, Combination therapy) in the US, Canada, France, Germany, Hungary, Japan, Poland, Romania and Spain (NCT07424404)
  • 29 Jan 2026 Phase-III clinical trials in Schizophrenia (In adolescents) in USA (unspecified route) (NCT07288567)
  • 23 Dec 2025 Registered for Schizophrenia in China (PO)

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