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Eflornithine oral - Orbus Therapeutics

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Drug Profile

Eflornithine oral - Orbus Therapeutics

Latest Information Update: 28 Nov 2025

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At a glance

  • Originator Orbus Therapeutics
  • Class Antihyperglycaemics; Antineoplastics; Basic amino acids; Diamino amino acids; Small molecules
  • Mechanism of Action Ornithine decarboxylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Anaplastic astrocytoma
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Anaplastic astrocytoma
  • Phase I Glioblastoma

Most Recent Events

  • 20 Nov 2025 Updated efficacy data from a phase III STELLAR trial in Astrocytoma released by Orbus Therapeutics
  • 25 Nov 2024 Interim efficacy and adverse events data from a phase III STELLAR trial in Astrocytoma released by Orbus Therapeutics
  • 26 May 2023 Phase-I clinical trials in Glioblastoma (First line therapy, Combination therapy) in USA (PO) (NCT05879367)

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