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Deucravacitinib - Bristol-Myers Squibb

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Drug Profile

Deucravacitinib - Bristol-Myers Squibb

Alternative Names: BMS-986165; BMS-986165-01; Sotyktu

Latest Information Update: 10 Oct 2025

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At a glance

  • Originator Bristol-Myers Squibb
  • Class Amides; Aniline compounds; Anti-inflammatories; Antipsoriatics; Antirheumatics; Cyclopropanes; Ethers; Hepatoprotectants; Organic deuterium compounds; Pyridazines; Skin disorder therapies; Small molecules; Triazoles; Urologics
  • Mechanism of Action TYK2 kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Plaque psoriasis
  • Registered Erythrodermic psoriasis; Pustular psoriasis
  • Preregistration Psoriatic arthritis
  • Phase III Juvenile rheumatoid arthritis; Psoriasis; Sjogren's syndrome; Systemic lupus erythematosus
  • Phase II Alopecia areata; Crohn's disease; Cutaneous lupus erythematosus; Discoid lupus erythematosus; Hidradenitis suppurativa; Lupus nephritis; Ulcerative colitis
  • No development reported Inflammatory bowel diseases

Most Recent Events

  • 25 Sep 2025 Phase-III clinical trials in Plaque psoriasis (In adolescents) in Canada, USA (PO) (NCT06979453)
  • 24 Sep 2025 Phase-III clinical trials in Plaque psoriasis in Romania, Mexico, Italy, Denmark, Chile, Bulgaria, Brazil, Belgium, Argentina (PO) (NCT07116967)
  • 24 Sep 2025 Bristol-Myers Squibb initiates the Phase-III PRAGMATYK trial in Plaque psoriasis in USA, Australia, Canada, China, Japan, Puerto Rico, South Korea, United Kingdom, Czech Republic, France, Germany, Hungary, Poland, Romania, , Spain, Sweden, Taiwan (PO) (NCT07116967)

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