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Umibecestat - Amgen

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Drug Profile

Umibecestat - Amgen

Alternative Names: AMG 520; CNP-250; CNP520

Latest Information Update: 13 Jan 2025

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At a glance

  • Originator Novartis
  • Developer Amgen; Novartis
  • Class Antidementias; Oxazines; Pyridines; Small molecules
  • Mechanism of Action Amyloid precursor protein secretase inhibitors; BACE1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Alzheimer's disease

Most Recent Events

  • 13 Jan 2025 Discontinued - Phase-II/III for Alzheimer's disease in Switzerland (PO)
  • 05 Aug 2021 Novartis and Amgen terminates the phase II/III GS2 trial in Alzheimer's disease in USA, Argentina, Australia, Belgium, Canada, Chile China, Finland, France, Germany, Iceland, Israel, Italy, Japan, Mexico, Netherlands, Portugal, Puerto Rico, Singapore, South Africa, South Korea, Spain, Switzerland, Taiwan and United Kingdom due to safety issues (NCT03131453)
  • 09 Aug 2019 Chemical structure information added

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