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Sonlicromanol - Khondrion

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Drug Profile

Sonlicromanol - Khondrion

Alternative Names: KH 176

Latest Information Update: 27 Jan 2025

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At a glance

  • Originator Khondrion
  • Class Antiparkinsonians; Benzopyrans; Piperidines; Small molecules
  • Mechanism of Action Prostaglandin-E synthase inhibitors; Reactive oxygen species modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Leigh disease; Mitochondrial disorders; MELAS syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Mitochondrial disorders
  • No development reported Parkinson's disease

Most Recent Events

  • 10 Jan 2025 Khondrion BV suspends a phase II trial in Mitochondrial disorders (In neonates, In infants, In children, In adolescents) in Netherlands (PO) due to strategic company decision, not related to safety concerns (EudraCT2020-003124-16)
  • 14 Nov 2024 US FDA approves IND application for sonlicromanol in Mitochondrial disorders
  • 14 Nov 2024 Khondrion plans a pivotal phase III trial in Mitochondrial disorders (PO) in 2025

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