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Trastuzumab deruxtecan - AstraZeneca/Daiichi Sankyo

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Drug Profile

Trastuzumab deruxtecan - AstraZeneca/Daiichi Sankyo

Alternative Names: DS 8201; DS 8201a; ENHERTU; Enhertu; fam-trastuzumab deruxtecan; fam-trastuzumab deruxtecan-nxki; T-DXd

Latest Information Update: 03 Jul 2026

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At a glance

  • Originator Daiichi Sankyo Company
  • Developer AstraZeneca; Bristol-Myers Squibb; Daiichi Sankyo Company; Medica Scientia Innovation Research; Seagen
  • Class Antineoplastics; Camptothecins; Drug conjugates; Immunoconjugates; Monoclonal antibodies
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastric cancer; Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Breast cancer; Gastric cancer; HER2 positive breast cancer; Non-small cell lung cancer; Solid tumours
  • Registered Adenocarcinoma
  • Phase III Biliary cancer; Endometrial cancer; Ovarian cancer
  • Phase II Colorectal cancer; Uterine cancer
  • Phase I/II Urogenital cancer

Most Recent Events

  • 29 Jun 2026 Registered for Solid tumours (Second-line therapy or greater, Metastatic disease, Inoperable/Unresectable, Monotherapy, In adults) in Norway, Liechtenstein, Iceland, European Union (IV)
  • 29 Jun 2026 Updated efficacy data from the phase-II DESTINY-PanTumor02 trial in Solid tumours released by AstraZeneca
  • 31 May 2026 Phase-I development is still underway for Breast-cancer(Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA, Belgium and France (IV, Infusion) (Daiichi Sankyo pipeline, May 2026)

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