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Trastuzumab deruxtecan - AstraZeneca/Daiichi Sankyo

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Drug Profile

Trastuzumab deruxtecan - AstraZeneca/Daiichi Sankyo

Alternative Names: DS 8201; DS 8201a; ENHERTU; Enhertu; fam-trastuzumab deruxtecan; fam-trastuzumab deruxtecan-nxki; T-DXd

Latest Information Update: 24 Oct 2025

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At a glance

  • Originator Daiichi Sankyo Company
  • Developer AstraZeneca; Bristol-Myers Squibb; Daiichi Sankyo Company; Medica Scientia Innovation Research; Seagen
  • Class Antineoplastics; Camptothecins; Drug conjugates; Immunoconjugates; Monoclonal antibodies
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastric cancer; Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Breast cancer; Gastric cancer; HER2 positive breast cancer; Non-small cell lung cancer; Solid tumours
  • Registered Adenocarcinoma
  • Phase III Biliary cancer; Endometrial cancer; Ovarian cancer
  • Phase II Colorectal cancer; Uterine cancer
  • Phase I/II Urogenital cancer

Most Recent Events

  • 18 Oct 2025 Updated adverse events and efficacy data from the phase-III DESTINY-Breast05 trial in Breast cancer released by AstraZeneca ,
  • 18 Oct 2025 Updated adverse events and efficacy data from the phase-III DESTINY-Breast11 trial in Breast cancer released by Daiichi Sankyo Company
  • 07 Oct 2025 Phase-III clinical trials in Non-small cell lung cancer (Metastatic disease, Late-stage disease, First-line therapy, Combination therapy, Inoperable/Unresectable) in Taiwan, South Korea, Japan, China (IV) (NCT06899126)

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