Trastuzumab deruxtecan - AstraZeneca/Daiichi Sankyo
Alternative Names: DS 8201; DS 8201a; ENHERTU; Enhertu; fam-trastuzumab deruxtecan; fam-trastuzumab deruxtecan-nxki; T-DXdLatest Information Update: 28 Aug 2025
At a glance
- Originator Daiichi Sankyo Company
- Developer AstraZeneca; Bristol-Myers Squibb; Daiichi Sankyo Company; Medica Scientia Innovation Research; Seagen
- Class Antineoplastics; Camptothecins; Drug conjugates; Immunoconjugates; Monoclonal antibodies
- Mechanism of Action DNA topoisomerase I inhibitors
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Marketed Breast cancer; Gastric cancer; HER2 positive breast cancer; Non-small cell lung cancer; Solid tumours
- Registered Adenocarcinoma
- Phase III Biliary cancer; Endometrial cancer; Ovarian cancer
- Phase II Colorectal cancer; Uterine cancer
- Phase I/II Urogenital cancer
Most Recent Events
- 28 Aug 2025 Daiichi Sankyo plans a phase I trial in Solid tumours (SC) (Daiichi Sankyo pipeline August 2025)
- 14 Aug 2025 Phase-III clinical trials in Non-small cell lung cancer (Combination therapy, First-line therapy, Late-stage disease, Inoperable/Unresectable, Metastatic disease) (IV) prior to August 2025 (NCT06899126)
- 06 Aug 2025 Phase-I clinical trials in Solid tumours (Metastatic disease, Late-stage disease, Second-line therapy or greater, Recurrent) in USA (SC) (NCT07015697)