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Trastuzumab deruxtecan - AstraZeneca/Daiichi Sankyo

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Drug Profile

Trastuzumab deruxtecan - AstraZeneca/Daiichi Sankyo

Alternative Names: DS 8201; DS 8201a; ENHERTU; Enhertu; fam-trastuzumab deruxtecan; fam-trastuzumab deruxtecan-nxki; T-DXd

Latest Information Update: 17 Apr 2026

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At a glance

  • Originator Daiichi Sankyo Company
  • Developer AstraZeneca; Bristol-Myers Squibb; Daiichi Sankyo Company; Medica Scientia Innovation Research; Seagen
  • Class Antineoplastics; Camptothecins; Drug conjugates; Immunoconjugates; Monoclonal antibodies
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastric cancer; Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Breast cancer; Gastric cancer; HER2 positive breast cancer; Non-small cell lung cancer; Solid tumours
  • Registered Adenocarcinoma
  • Phase III Biliary cancer; Endometrial cancer; Ovarian cancer
  • Phase II Colorectal cancer; Uterine cancer
  • Phase I/II Urogenital cancer

Most Recent Events

  • 27 Mar 2026 Registered for HER2-positive-breast-cancer (Neoadjuvant therapy, Early-stage disease, First-line therapy) in China (IV)
  • 23 Mar 2026 Registered for Solid tumours (Late-stage disease, Inoperable/Unresectable, Second-line therapy or greater, Metastatic disease) in Japan (IV)
  • 23 Mar 2026 PMDA approves Trastuzumab deruxtecan for second-line treatment of Gastric cancer in Japan (IV, Infusion)

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