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Apraglutide - Ironwood Pharmaceuticals

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Drug Profile

Apraglutide - Ironwood Pharmaceuticals

Alternative Names: FE 203799; GLP2 analouge; Glucagon-like peptide-2 receptor agonist - Ferring Pharmaceuticals/Ironwood Pharmaceuticals

Latest Information Update: 05 Mar 2026

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At a glance

  • Originator Ferring Pharmaceuticals
  • Developer Ironwood Pharmaceuticals; Therachon
  • Class Glucagon-like peptides
  • Mechanism of Action Glucagon-like peptide 2 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Graft-versus-host disease; Short bowel syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Short bowel syndrome
  • Phase I Unspecified
  • No development reported Gastrointestinal disorders
  • Discontinued Graft-versus-host disease

Most Recent Events

  • 25 Feb 2026 Ironwood Pharmaceuticals plans a confirmatory phase III STARS-2 trial for Short bowel syndrome in USA (SC), in the second half of 2026
  • 07 Aug 2025 Efficacy data from the phase III STARS Extend trial in Short bowel syndrome released by
  • 07 Aug 2025 Ironwood Pharmaceuticals announces intention to align with the FDA, in the fourth quarter of 2025

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