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Pegzilarginase - Immedica

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Drug Profile

Pegzilarginase - Immedica

Alternative Names: AEB-1102; AERase; Co-ArgI-PEG - Spyre Therapeutics; Co-ArgI-PEG modified human arginase I - Spyre Therapeutics; Loargys; Optimised human arginase I - Spyre Therapeutics; PEG-arginase - Spyre Therapeutics; Pegarginase - Spyre Therapeutics; Pegzilarginase-nbln - Spyre Therapuetics

Latest Information Update: 27 Feb 2026

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At a glance

  • Originator Aeglea Biotherapeutics
  • Developer Aeglea Biotherapeutics; Immedica; Merck AG; Spyre Therapeutics
  • Class Antineoplastics; Enzymes; Immunotherapies; Polyethylene glycols; Recombinant proteins; Ureohydrolases
  • Mechanism of Action Arginase replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hyperargininaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Hyperargininaemia
  • Phase I/II Small cell lung cancer
  • No development reported Non-small cell lung cancer; Solid tumours
  • Discontinued Acute myeloid leukaemia; Myelodysplastic syndromes

Most Recent Events

  • 23 Feb 2026 Registered for Hyperargininaemia (In children, In adolescents, In the elderly, In adults) in USA (IV)
  • 23 Feb 2026 Immedica plans to launch Pegzilarginase for Hyperargininaemia in USA in April 2026
  • 31 Oct 2025 Preregistration for Hyperargininaemia in Canada (IV)

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