Drug Profile

Fuzuloparib - Jiangsu HengRui Medicine

Alternative Names: Fluzoparib; HS-10160; SHR 3162

Latest Information Update: 12 Mar 2025

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At a glance

Originator Jiangsu Hengrui Medicine Co.
Developer Chinese PLA General Hospital; Jiangsu Hengrui Medicine Co.; Tianjin Medical University Cancer Institute and Hospital
Class 2 ring heterocyclic compounds; Antineoplastics; Fluorobenzenes; Phthalazines; Pyrazines; Small molecules; Triazoles
Mechanism of Action Poly(ADP-ribose) polymerase 2 inhibitors; Poly(ADP-ribose) polymerase-1 inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes
Available For Licensing Yes - Solid tumours

Marketed Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
Phase III HER2 negative breast cancer; Pancreatic cancer; Prostate cancer
Phase II Glioblastoma
Phase I/II Small cell lung cancer
No development reported Gastric cancer; Solid tumours; Triple negative breast cancer

01 Nov 2024 Jiangsu HengRui Medicine completes a phase II clinical trial in Ovarian cancer (Combination therapy) in China (PO) (NCT04517357)
13 Sep 2024 Efficacy, safety, pharmacokinetics and drug interactions data from a phase II trial in Prostate cancer presented at the 49^th European Society for Medical Oncology Congress (ESMO-2024)
13 Sep 2024 Efficacy and adverse events data from the phase II trial in Solid tumours presented at the 49^th European Society for Medical Oncology Congress (ESMO-2024)

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