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Ranibizumab biosimilar - Xbrane

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Drug Profile

Ranibizumab biosimilar - Xbrane

Alternative Names: Lucamzi; VA-2; Ximluci; Xlucane

Latest Information Update: 06 Feb 2026

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At a glance

  • Originator Xbrane
  • Class Eye disorder therapies; Immunoglobulin fragments; Monoclonal antibodies
  • Mechanism of Action Angiogenesis inhibitors; Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Marketed Choroidal neovascularisation; Diabetic macular oedema; Diabetic retinopathy; Retinal vein occlusion; Wet age-related macular degeneration
  • Preregistration Degenerative myopia; Retinal oedema

Most Recent Events

  • 06 Feb 2026 No development reported - Phase-III for Wet age-related macular degeneration (In adults, In the elderly, Newly diagnosed) in Ukraine, Russia, Israel, India (Intravitreous)
  • 10 Dec 2025 Ximluci® is still in reg phase for wet age-related macular degeneration, diabetic macular oedema, diabetic retinopathy, retinal vein occlusion, choroidal neovascularisation in EU, Norway, Iceland and Liechtenstein (Xbrane website, December 2025)
  • 19 Nov 2025 The US FDA sets BsUFA date of September 2026 for ranibizumab biosimilar for retinal disorders

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