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Ripretinib - Deciphera Pharmaceuticals

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Drug Profile

Ripretinib - Deciphera Pharmaceuticals

Alternative Names: DCC-2618; QINLOCK

Latest Information Update: 03 Jan 2025

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At a glance

  • Originator Deciphera Pharmaceuticals
  • Developer Deciphera Pharmaceuticals; Specialised Therapeutics Asia; ZAI Lab
  • Class Amines; Antineoplastics; Bromobenzenes; Cyclopropanes; Fluorinated hydrocarbons; Naphthyridines; Phenylurea compounds; Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action Platelet-derived growth factor alpha receptor antagonists; Platelet-derived growth factor beta receptor antagonists; Proto-oncogene protein b-raf inhibitors; Proto-oncogene protein c-kit expression inhibitors; TIE-2 receptor antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma; Gastrointestinal stromal tumours; Anaplastic astrocytoma
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Marketed Gastrointestinal stromal tumours
  • Phase I Solid tumours; Systemic mastocytosis
  • No development reported Glioblastoma

Most Recent Events

  • 13 Sep 2024 Adverse events and efficacy data from a phase II trial for Gastrointestinal stromal tumors presented at the 49th European Society for Medical Oncology Congress (ESMO-2024)
  • 29 Jul 2024 Deciphera Pharmaceuticals completes a phase I trial in Gastrointestinal stromal tumours (Combination therapy; Late-stage disease, Second-line therapy or greater) in USA (NCT04530981)
  • 11 Jun 2024 Deciphera Pharmaceuticals has been acquired by Ono Pharmaceutical

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