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Ripretinib - Deciphera Pharmaceuticals

Drug Profile

Ripretinib - Deciphera Pharmaceuticals

Alternative Names: DCC-2618; QINLOCK

Latest Information Update: 14 Oct 2020

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At a glance

  • Originator Deciphera Pharmaceuticals
  • Developer Deciphera Pharmaceuticals; ZAI Lab
  • Class Amines; Antineoplastics; Bromobenzenes; Cyclopropanes; Fluorinated hydrocarbons; Naphthyridines; Phenylurea compounds; Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action Platelet derived growth factor alpha receptor antagonists; Platelet-derived growth factor beta receptor antagonists; Proto oncogene protein b raf inhibitors; Proto-oncogene protein c-kit expression inhibitors; TIE 2 receptor antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastrointestinal stromal tumours; Glioblastoma; Anaplastic astrocytoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Gastrointestinal stromal tumours
  • Phase I Glioblastoma; Solid tumours; Systemic mastocytosis

Most Recent Events

  • 22 Sep 2020 Updated safety and efficacy data from the phase III INVICTUS trial in Gastrointestinal stromal tumours released by Deciphera Pharmaceuticals
  • 19 Sep 2020 Updated safety data from a phase I trial in Gastrointestinal stromal tumours presented at 45th European Society for Medical Oncology Congress (ESMO-2020)
  • 28 Aug 2020 Deciphera Pharmaceuticals plans a phase I trial in Gastrointestinal stromal tumours in November 2020 (NCT04530981)
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