Avapritinib - Blueprint Medicines

Drug Profile

Avapritinib - Blueprint Medicines

Alternative Names: BLU 285

Latest Information Update: 17 Oct 2018

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At a glance

  • Originator Blueprint Medicines
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Platelet derived growth factor alpha receptor antagonists; Proto oncogene protein c-kit inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Systemic mastocytosis; Gastrointestinal stromal tumours
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Gastrointestinal stromal tumours
  • Phase II Systemic mastocytosis
  • Phase I Solid tumours

Most Recent Events

  • 01 Oct 2018 Phase-II clinical trials in Systemic mastocytosis (Late-stage disease, Second-line therapy or greater) in USA (PO) (NCT03580655)
  • 28 Sep 2018 Phase-I development is ongoing in Gastrointestinal-stromal-tumours(Inoperable/Unresectable, Metastatic disease, Second-line therapy or greater) in Netherlands, Germany, Belgium (PO) (NCT02508532)
  • 28 Sep 2018 Phase-I development is ongoing in Solid-tumours (Late-stage disease, Second-line therapy or greater) in Belgium, France, Germany, Netherlands, United Kingdom and USA (PO) (NCT02508532)
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