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Avapritinib - Blueprint Medicines

Drug Profile

Avapritinib - Blueprint Medicines

Alternative Names: AYVAKIT; BLU 285; CS 3007

Latest Information Update: 16 Jan 2020

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At a glance

  • Originator Blueprint Medicines
  • Class 2 ring heterocyclic compounds; Amines; Antineoplastics; Pyrazoles; Pyrimidines; Pyrroles; Skin disorder therapies; Small molecules; Triazines
  • Mechanism of Action Platelet derived growth factor alpha receptor antagonists; Proto oncogene protein c-kit inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Systemic mastocytosis; Gastrointestinal stromal tumours
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Gastrointestinal stromal tumours
  • Phase II Haematological malignancies; Systemic mastocytosis
  • Phase I Solid tumours

Most Recent Events

  • 09 Jan 2020 Registered for Gastrointestinal stromal tumours (Inoperable/Unresectable, Metastatic disease) in USA (PO)-first global approval
  • 09 Jan 2020 FDA assigns PDUFA action date of 14/02/2020 for avapritinib for fourth-line Gastrointestinal stromal tumours
  • 09 Jan 2020 Additional efficacy data from the phase I NAVIGATOR trial in Gastrointestinal stromal tumour released by Blueprint Medicines
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