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Epeleuton - Afimmune

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Drug Profile

Epeleuton - Afimmune

Alternative Names: 15-HEPE; 5-hydroxyeicosapentaenoic acid; AF-102 - Afimmune; DS 102

Latest Information Update: 12 Dec 2024

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At a glance

  • Originator DS Biopharma
  • Developer Afimmune; DS Biopharma
  • Class Anti-inflammatories; Antianaemics; Antifibrotics; Antihyperglycaemics; Hepatoprotectants; Pentanoic acids; Vascular disorder therapies
  • Mechanism of Action 5-lipoxygenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Sickle cell anaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alcoholic hepatitis; Chronic obstructive pulmonary disease; Diabetic neuropathies; Hypertriglyceridaemia; Idiopathic pulmonary fibrosis; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Sickle cell anaemia; Type 2 diabetes mellitus
  • Preclinical Atherosclerosis; COVID 2019 infections
  • No development reported Hepatic fibrosis

Most Recent Events

  • 18 Sep 2024 US PTO issues patent for epeleuton in Sickle cell disease in USA
  • 09 Dec 2023 Pharmacodynamics data from a preclinical trial in Sickle cell disease presented at the 65th American Society of Hematology Annual Meeting (ASH-2023)
  • 08 Nov 2023 Epeleuton - Afimmune receives Fast Track designation for Sickle cell anaemia [PO,Capsule] in USA

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